
Rice Science ›› 2025, Vol. 32 ›› Issue (5): 649-657.DOI: 10.1016/j.rsci.2025.06.005
收稿日期:2025-04-10
接受日期:2025-06-04
出版日期:2025-09-28
发布日期:2025-10-11
. [J]. Rice Science, 2025, 32(5): 649-657.
| [1] | Alfatih A, Wu J, Jan S U, et al. 2020. Loss of rice PARAQUAT TOLERANCE 3 confers enhanced resistance to abiotic stresses and increases grain yield in field. Plant Cell Environ, 43(11): 2743-2754. |
| [2] | Amerik A Y, Hochstrasser M. 2004. Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta, 1695(1/3): 189-207. |
| [3] | Bai C, Wang G J, Feng X H, et al. 2024. OsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate. Nat Commun, 15: 4300. |
| [4] | Bessho-Uehara K, Masuda K, Wang D R, et al. 2023. Regulator of Awn Elongation 3, an E3 ubiquitin ligase, is responsible for loss of awns during African rice domestication. Proc Natl Acad Sci USA, 120(4): e2207105120. |
| [5] | Bi Y, Wang H, Yuan X, et al. 2023. The NAC transcription factor ONAC083 negatively regulates rice immunity against Magnaporthe oryzae by directly activating transcription of the RING-H2 gene OsRFPH2-6. J Integr Plant Biol, 65(3): 854-875. |
| [6] | Borah P, Khurana J P. 2018. The OsFBK1 E3 ligase subunit affects anther and root secondary cell wall thickenings by mediating turnover of a cinnamoyl-CoA reductase. Plant Physiol, 176(3): 2148-2165. |
| [7] | Borah P, Sharma A, Sharma A K, et al. 2023. SCFOsFBK1 E3 ligase mediates jasmonic acid-induced turnover of OsATL53 and OsCCR14 to regulate lignification of rice anthers and roots. J Exp Bot, 74(19): 6188-6204. |
| [8] | Borna R S, Murchie E H, Pyke K A, et al. 2022. The rice EP3 and OsFBK1 E3 ligases alter plant architecture and flower development, and affect transcript accumulation of microRNA pathway genes and their targets. Plant Biotechnol J, 20(2): 297-309. |
| [9] | Chen S J, Xu K, Kong D Y, et al. 2022. Ubiquitin ligase OsRINGzf1 regulates drought resistance by controlling the turnover of OsPIP2;1. Plant Biotechnol J, 20( 9): 1743-1755. |
| [10] | Choi C, Im J H, Lee J, et al. 2022. OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice. Plant J, 112(4): 966-981. |
| [11] | Cui L H, Min H J, Yu S G, et al. 2022. OsATL38 mediates mono-ubiquitination of the 14-3-3 protein OsGF14d and negatively regulates the cold stress response in rice. J Exp Bot, 73(1): 307-323. |
| [12] | Fan J J, Ma X, Zou J, et al. 2024. LATA1, a RING E3 ligase, modulates the tiller angle by affecting auxin asymmetric distribution and content in rice. Plant J, 120(2): 429-444. |
| [13] | Fu S, Wang K, Ma T T, et al. 2022. An evolutionarily conserved C4HC3-type E3 ligase regulates plant broad-spectrum resistance against pathogens. Plant Cell, 34(5): 1822-1843. |
| [14] | Gao M J, He Y, Yin X, et al. 2021. Ca2+ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector. Cell, 184(21): 5391-5404.e17. |
| [15] | Gu P Y, Tao W Q, Tao J Y, et al. 2023. The D14-SDEL1-SPX4 cascade integrates the strigolactone and phosphate signalling networks in rice. New Phytol, 239(2): 673-686. |
| [16] | Guo L N, Chen W L, Tao L, et al. 2020. GWC1 is essential for high grain quality in rice. Plant Sci, 296: 110497. |
| [17] | Hao J Q, Wang D K, Wu Y B, et al. 2021. The GW2-WG1-OsbZIP47 pathway controls grain size and weight in rice. Mol Plant, 14(8): 1266-1280. |
| [18] | Hao Q X, Zhu X J, Huang Y S, et al. 2024. E3 ligase DECREASED GRAIN SIZE 1 promotes degradation of a G-protein subunit and positively regulates grain size in rice. Plant Physiol, 196(2): 948-960. |
| [19] | Hoeller D, Crosetto N, Blagoev B, et al. 2006. Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol, 8(2): 163-169. |
| [20] | Hsu K H, Liu C C, Wu S J, et al. 2014. Expression of a gene encoding a rice RING zinc-finger protein, OsRZFP34, enhances stomata opening. Plant Mol Biol, 86(1/2): 125-137. |
| [21] | Hua Z H, Vierstra R D. 2011. The cullin-RING ubiquitin-protein ligases. Annu Rev Plant Biol, 62: 299-334. |
| [22] | Huang K, Wang D K, Duan P G, et al. 2017. WIDE AND THICK GRAIN 1, which encodes an otubain-like protease with deubiquitination activity, influences grain size and shape in rice. Plant J, 91(5): 849-860. |
| [23] | Huang L J, Hua K, Xu R, et al. 2021. The LARGE2-APO1/APO2 regulatory module controls panicle size and grain number in rice. Plant Cell, 33(4): 1212-1228. |
| [24] | Huang X E, Chen X H, Vergish S, et al. 2025. Over-expression of XA21 binding protein 3 enhances rice survival under water-deficit stress. Plant Sci, 354: 112454. |
| [25] | Ishikawa K, Yamaguchi K, Sakamoto K, et al. 2014. Bacterial effector modulation of host E3 ligase activity suppresses PAMP-triggered immunity in rice. Nat Commun, 5: 5430. |
| [26] | Jamil A, Riaz S, Ashraf M, et al. 2011. Gene expression profiling of plants under salt stress. Crit Rev Plant Sci, 30(5): 435-458. |
| [27] | Kachewar N R, Gupta V, Ranjan A, et al. 2019. Overexpression of OsPUB41, a rice E3 ubiquitin ligase induced by cell wall degrading enzymes, enhances immune responses in rice and Arabidopsis. BMC Plant Biol, 19(1): 530. |
| [28] | Kim B, Piao R, Lee G, et al. 2021. OsCOP1 regulates embryo development and flavonoid biosynthesis in rice (Oryza sativa L.). Theor Appl Genet, 134(8): 2587-2601. |
| [29] | Kim J H, Jang C S. 2021. E3 ligase, the Oryza sativa salt-induced RING finger protein 4 (OsSIRP4), negatively regulates salt stress responses via degradation of the OsPEX11-1 protein. Plant Mol Biol, 105(3): 231-245. |
| [30] | Kim J H, Lim S D, Jang C S. 2019. Oryza sativa heat-induced RING finger protein 1 (OsHIRP1) positively regulates plant response to heat stress. Plant Mol Biol, 99(6): 545-559. |
| [31] | Kim J H, Lim S D, Jang C S. 2021. Oryza sativa, C4HC3-type really interesting new gene (RING), OsRFPv6, is a positive regulator in response to salt stress by regulating Na+ absorption. Physiol Plant, 173(3): 883-895. |
| [32] | Kim J H, Lim S D, Jung K H, et al. 2023. Overexpression of a C3HC4-type E3-ubiquitin ligase contributes to salinity tolerance by modulating Na+ homeostasis in rice. Physiol Plant, 175(6): e14075. |
| [33] | Kim M S, Ko S R, Jung Y J, et al. 2023. Knockout mutants of OsPUB7 generated using CRISPR/Cas9 revealed abiotic stress tolerance in rice. Int J Mol Sci, 24(6): 5338. |
| [34] | Leitner J, Petrášek J, Tomanov K, et al. 2012. Lysine63-linked ubiquitylation of PIN2 auxin carrier protein governs hormonally controlled adaptation of Arabidopsis root growth. Proc Natl Acad Sci USA, 109(21): 8322-8327. |
| [35] | Li H, Wang Y P, Qiao W H, et al. 2024. Identification of a novel locus qGW12/OsPUB23 regulating grain shape and weight in rice (Oryza sativa L.). Theor Appl Genet, 137(12): 267. |
| [36] | Li J, Zhang B L, Duan P G, et al. 2023. An endoplasmic reticulum-associated degradation-related E2-E3 enzyme pair controls grain size and weight through the brassinosteroid signaling pathway in rice. Plant Cell, 35(3): 1076-1091. |
| [37] | Li X X, Yu B, Wu Q, et al. 2021. OsMADS23 phosphorylated by SAPK9 confers drought and salt tolerance by regulating ABA biosynthesis in rice. PLoS Genet, 17(8): e1009699. |
| [38] | Li Y, Ren M Y, Wu Y R, et al. 2025. A root system architecture regulator modulates OsPIN2 polar localization in rice. Nat Commun, 16: 15. |
| [39] | Liu D P, Zhang X X, Li Q L, et al. 2023. The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice. Plant Commun, 4(2): 100450. |
| [40] | Liu J P, Zhang C C, Wei C C, et al. 2016. The RING finger ubiquitin E3 ligase OsHTAS enhances heat tolerance by promoting H2O2-induced stomatal closure in rice. Plant Physiol, 170(1): 429-443. |
| [41] | Liu J P, Nie B, Yu B L, et al. 2023. Rice ubiquitin-conjugating enzyme OsUbc13 negatively regulates immunity against pathogens by enhancing the activity of OsSnRK1a. Plant Biotechnol J, 21(8): 1590-1610. |
| [42] | Liu W, Li J, Sun J, et al. 2025. The E3 ligase OsHel2 impedes readthrough of stalled mRNAs to regulate male fertility in thermo-sensitive genic male sterile rice. Plant Commun, 6(2): 101192. |
| [43] | Liu Y, Jackson E, Liu X, et al. 2024. Proteolysis in plant immunity. Plant Cell, 36(9): 3099-3115. |
| [44] | Liu Z Q, Qiu J H, Shen Z N, et al. 2023. The E3 ubiquitin ligase OsRGLG5 targeted by the Magnaporthe oryzae effector AvrPi9 confers basal resistance against rice blast. Plant Commun, 4(5): 100626. |
| [45] | Luo M, Zhu S T, Dang H, et al. 2025. Genetically-encoded targeted protein degradation technology to remove endogenous condensation-prone proteins and improve crop performance. Nat Commun, 16(1): 1159. |
| [46] | Lv Q L, Li X X, Jin X K, et al. 2022. Rice OsPUB16 modulates the ‘SAPK9-OsMADS23-OsAOC’ pathway to reduce plant water-deficit tolerance by repressing ABA and JA biosynthesis. PLoS Genet, 18(11): e1010520. |
| [47] | Ly L K, Ho T M, Bui T P, et al. 2024. CRISPR/Cas9 targeted mutations of OsDSG1 gene enhanced salt tolerance in rice. Funct Integr Genomics, 24(2): 70. |
| [48] | Ma N N, Li N, Yu Z M, et al. 2023. The F-box protein SHORT PRIMARY ROOT modulates primary root meristem activity by targeting SEUSS-LIKE protein for degradation in rice. J Integr Plant Biol, 65(8): 1937-1949. |
| [49] | Ma S Q, Tang N, Li X, et al. 2019. Reversible histone H2B monoubiquitination fine-tunes abscisic acid signaling and drought response in rice. Mol Plant, 12(2): 263-277. |
| [50] | Ma X Y, Claus L A N, Leslie M E, et al. 2020. Ligand-induced monoubiquitination of BIK1 regulates plant immunity. Nature, 581: 199-203. |
| [51] | Ning Y S, Jantasuriyarat C, Zhao Q Z, et al. 2011. The SINA E3 ligase OsDIS1 negatively regulates drought response in rice. Plant Physiol, 157(1): 242-255. |
| [52] | Park G G, Park J J, Yoon J, et al. 2010. A RING finger E3 ligase gene, Oryza sativa Delayed Seed Germination 1 (OsDSG1), controls seed germination and stress responses in rice. Plant Mol Biol, 74(4/5): 467-478. |
| [53] | Park Y C, Lim S D, Moon J C, et al. 2019. A rice really interesting new gene H2-type E3 ligase, OsSIRH2-14, enhances salinity tolerance via ubiquitin/26S proteasome-mediated degradation of salt-related proteins. Plant Cell Environ, 42(11): 3061-3076. |
| [54] | Peng G Q, Liu M L, Luo Z L, et al. 2024. An E3 ubiquitin ligase CSIT2 controls critical sterility-inducing temperature of thermo-sensitive genic male sterile rice. New Phytol, 241(5): 2059-2074. |
| [55] | Pickart C M, Fushman D. 2004. Polyubiquitin chains: Polymeric protein signals. Curr Opin Chem Biol, 8(6): 610-616. |
| [56] | Qin Q, Wang Y X, Huang L Y, et al. 2020. A U-box E3 ubiquitin ligase OsPUB67 is positively involved in drought tolerance in rice. Plant Mol Biol, 102(1/2): 89-107. |
| [57] | Ren L J, Zhao T T, Zhao Y Z, et al. 2021. The E3 ubiquitin ligase DESYNAPSIS1 regulates synapsis and recombination in rice meiosis. Cell Rep, 37(5): 109941. |
| [58] | Seo D H, Lee A, Yu S G, et al. 2021. OsPUB41, a U-box E3 ubiquitin ligase, acts as a negative regulator of drought stress response in rice (Oryza sativa L.). Plant Mol Biol, 106(4/5): 463-477. |
| [59] | Shi C L, Ren Y L, Liu L L, et al. 2019. Ubiquitin specific protease 15 has an important role in regulating grain width and size in rice. Plant Physiol, 180(1): 381-391. |
| [60] | Shi H, Yin J J, Zhao Z J, et al. 2024. Fine-tuning of IPA1 transactivation activity by E3 ligase IPI7-mediated non-proteolytic K29-ubiquitination during Magnaporthe oryzae infection. Nat Commun, 15(1): 7608. |
| [61] | Song X G, Meng X B, Guo H Y, et al. 2022. Targeting a gene regulatory element enhances rice grain yield by decoupling panicle number and size. Nat Biotechnol, 40(9): 1403-1411. |
| [62] | Song X J, Huang W, Shi M, et al. 2007. A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase. Nat Genet, 39(5): 623-630. |
| [63] | Sun J, Song W, Chang Y, et al. 2022. OsLMP1, encoding a deubiquitinase, regulates the immune response in rice. Front Plant Sci, 12: 814465. |
| [64] | Sun J Y, Zhou Z R, Wang Y Q, et al. 2024. OsHRZ1 negatively regulates rice resistant to Magnaporthe oryzae infection by targeting OsVOZ2. Transgenic Res, 33(5): 489-501. |
| [65] | Sun X X, Xie Y H, Xu K Z, et al. 2024. Regulatory networks of the F-box protein FBX206 and OVATE family proteins modulate brassinosteroid biosynthesis to regulate grain size and yield in rice. J Exp Bot, 75(3): 789-801. |
| [66] | Sun Y, Gu X Y, Qu C F, et al. 2024. OsPUB75-OsHDA716 mediates deactivation and degradation of OsbZIP46 to negatively regulate drought tolerance in rice. Plant Physiol, 197(1): kiae545. |
| [67] | Tan Q, Zhang X, Luo Q, et al. 2024. The RING domain of rice HEI10 is essential for male, but not female fertility. Rice, 17(1): 3. |
| [68] | Tang N, Zhang H, Li X H, et al. 2012. Constitutive activation of transcription factor OsbZIP46 improves drought tolerance in rice. Plant Physiol, 158(4): 1755-1768. |
| [69] | Tang N, Ma S Q, Zong W, et al. 2016. MODD mediates deactivation and degradation of OsbZIP46 to negatively regulate ABA signaling and drought resistance in rice. Plant Cell, 28(9): 2161-2177. |
| [70] | Tang S, Zhao Z Y, Liu X T, et al. 2023. An E2-E3 pair contributes to seed size control in grain crops. Nat Commun, 14(1): 3091. |
| [71] | Tao H, Xiao N, Wang R Y, et al. 2025. Development of elite rice with broad-spectrum resistance through pyramiding of key resistance gene and simultaneously editing multiple susceptibility genes. J Integr Plant Biol, 67(7): 1691-1693. |
| [72] | Wang G, Chen X, Yu C Z, et al. 2024. Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice. Nature, 629: 1158-1164. |
| [73] | Wang K, Fu S, Wu L, et al. 2023a. Rice stripe virus nonstructural protein 3 suppresses plant defence responses mediated by the MEL-SHMT1 module. Mol Plant Pathol, 24(11): 1359-1369. |
| [74] | Wang K, Li S, Chen L X, et al. 2023b. E3 ubiquitin ligase OsPIE3 destabilises the B-lectin receptor-like kinase PID2 to control blast disease resistance in rice. New Phytol, 237(5): 1826-1842. |
| [75] | Wang K J, Wang M, Tang D, et al. 2012. The role of rice HEI10 in the formation of meiotic crossovers. PLoS Genet, 8(7): e1002809. |
| [76] | Wang R Y, You X M, Zhang C Y, et al. 2022. An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome. Genome Biol, 23(1): 154. |
| [77] | Wang S, Han S Y, Zhou X G, et al. 2023. Phosphorylation and ubiquitination of OsWRKY31 are integral to OsMKK10-2-mediated defense responses in rice. Plant Cell, 35(6): 2391-2412. |
| [78] | Wang S L, Zhang Z H, Fan Y Y, et al. 2022. Control of grain weight and size in rice (Oryza sativa L.) by OsPUB3 encoding a U-box E3 ubiquitin ligase. Rice, 15(1): 58. |
| [79] | Wang Y, Zheng C, Peng Y L, et al. 2024. DGS1 improves rice disease resistance by elevating pathogen-associated molecular pattern-triggered immunity. aBIOTECH, 5(1): 46-51. |
| [80] | Wang Y S, Pi L Y, Chen X H, et al. 2006. Rice XA21 binding protein 3 is a ubiquitin ligase required for full Xa21-mediated disease resistance. Plant Cell, 18(12): 3635-3646. |
| [81] | Wang Z Y, Tian X J, Zhao Q Z, et al. 2018. The E3 ligase DROUGHT HYPERSENSITIVE negatively regulates cuticular wax biosynthesis by promoting the degradation of transcription factor ROC4 in rice. Plant Cell, 30(1): 228-244. |
| [82] | Wen Y, Hu P, Fang Y X, et al. 2024. GW9 determines grain size and floral organ identity in rice. Plant Biotechnol J, 22(4): 915-928. |
| [83] | Wu Q, Liu Y F, Huang J L. 2022. CRISPR-Cas9 mediated mutation in OsPUB43 improves grain length and weight in rice by promoting cell proliferation in spikelet hull. Int J Mol Sci, 23(4): 2347. |
| [84] | Xiao L Y, Shi Y Y, Wang R, et al. 2022. The transcription factor OsMYBc and an E3 ligase regulate expression of a K+ transporter during salt stress. Plant Physiol, 190(1): 843-859. |
| [85] | Xie Y H, Fan Z P, Liang X Y, et al. 2025. OsPUB9 modulates leaf angle and grain size through the brassinosteroid signaling pathway in rice. Plant J, 121(3): e17230. |
| [86] | Xie Z Z, Sun Y, Zhan C H, et al. 2024. The E3 ligase OsPUB33 controls rice grain size and weight by regulating the OsNAC120-BG1 module. Plant Cell, 37(1): koae297. |
| [87] | Xu X, Shi X T, You X M, et al. 2024. A pair of E3 ubiquitin ligases control immunity and flowering by targeting different ELF3 proteins in rice. Dev Cell, 59(20): 2731-2744.e4. |
| [88] | Yan Y Q, Wang H, Bi Y, et al. 2024. OsATL32 ubiquitinates the reactive oxygen species-producing OsRac5-OsRbohB module to suppress rice immunity. J Integr Plant Biol, 66(7): 1459-1480. |
| [89] | Yang W S, Wu K, Wang B, et al. 2021. The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice. Mol Plant, 14(10): 1699-1713. |
| [90] | Yi H, Shi H, Mao W, et al. 2024. E3 ubiquitin ligase IPI1 controls rice immunity and flowering via both E3 ligase-dependent and -independent pathways. Dev Cell, 59(20): 2719-2730.e4. |
| [91] | You Q Y, Zhai K R, Yang D L, et al. 2016. An E3 ubiquitin ligase-BAG protein module controls plant innate immunity and broad-spectrum disease resistance. Cell Host Microbe, 20(6): 758-769. |
| [92] | You X M, Zhang F, Liu Z, et al. 2022. Rice catalase OsCATC is degraded by E3 ligase APIP6 to negatively regulate immunity. Plant Physiol, 190(2): 1095-1099. |
| [93] | Yue Z C, Wang Z P, Yao Y L, et al. 2024. Variation in WIDTH OF LEAF AND GRAIN contributes to grain and leaf size by controlling LARGE2 stability in rice. Plant Cell, 36(9): 3201-3218. |
| [94] | Zhai K R, Liang D, Li H L, et al. 2022. NLRs guard metabolism to coordinate pattern- and effector-triggered immunity. Nature, 601: 245-251. |
| [95] | Zhang C Y, Fang H, Wang J S, et al. 2024. The rice E3 ubiquitin ligase-transcription factor module targets two trypsin inhibitors to enhance broad-spectrum disease resistance. Dev Cell, 59(15): 2017-2033.e5. |
| [96] | Zhang C Y, Fang L, He F, et al. 2025. Ubiquitination of OsCSN5 by OsPUB45 activates immunity by modulating the OsCUL3a-OsNPR1 module. Sci Adv, 11(1): eadr2441. |
| [97] | Zhang H, Zhou J F, Kan Y, et al. 2022. A genetic module at one locus in rice protects chloroplasts to enhance thermotolerance. Science, 376: 1293-1300. |
| [98] | Zhang H, Huang D R, Shen Y, et al. 2024. GL5.2, a quantitative trait locus for rice grain shape, encodes a RING-type E3 ubiquitin ligase. Plants, 13(17): 2521. |
| [99] | Zhang J, Du Q, Wu Y G, et al. 2025. Ubiquitin ligase gene OsPUB57 negatively regulates rice blast resistance. Plants, 14(5): 758. |
| [100] | Zhao W J, Wen J L, Zhao J, et al. 2025. E3 ubiquitin ligase OsRFI2 regulates salinity tolerance by targeting ascorbate peroxidase OsAPX8 for its degradation in rice. Rice, 18(1): 12. |
| [101] | Zhao Y D, Zhong X H, Xu G J, et al. 2024. The F-box protein OsFBX156 positively regulates rice defence against the blast fungus Magnaporthe oryzae by mediating ubiquitination-dependent degradation of OsHSP71.1. Mol Plant Pathol, 25(6): e13459. |
| [102] | Zheng Y Y, Zhang S S, Luo Y Q, et al. 2022. Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation. Plant Commun, 3(6): 100412. |
| No related articles found! |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||