Abstract: As sessile organisms, plants must overcome various stresses. Accordingly, they have evolved several plant-specific growth and developmental processes. WRKY53 is a member of the WRKY transcription factor family, which plays a crucial role in rice growth and development, stress responses, and hormone signal transduction. This review discusses the role of WRKY53 in stress responses, particularly its functions in cold tolerance, salt tolerance, disease resistance, and pest defense and explores its role in regulating rice leaf senescence and seed germination. This article also proposes future research directions, including functional genomics studies, protein interaction network analysis, hormone signal transduction pathways, genetic improvement strategies, application of gene editing technologies, molecular basis of stress responses, cross-species functional conservation, and bioinformatics and comparative genomics research. This review highlights the importance of WRKY53 in rice biology and provides new perspectives and strategies for future research and genetic improvement of rice.

Key words: WRKY53, rice, stress response, signal transduction, growth and development, genetic improvement