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Function of R2R3-type Myeloblastosis Transcription Factors in Plants

  1. Precision Medicine Laboratory for Chronic Non-communicable Diseases of Shandong Province, Institute of Precision Medicine, Jining Medical University, Jining 272000, China; Institute of Bioengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Centre, Zhejiang University, Hangzhou 311200, China; Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200030, China; Key Laboratory of Plant Genetics and Molecular Breeding, Zhoukou Normal University, Zhoukou 466001, China; #These authors contributed equally to this work
  • Contact: SUN Bo; TAO Zhihuan
  • Supported by:

    This study was supported by the Faculty Startup Fund from Jining Medical University, the Shandong Provincial Natural Science Foundation, China (Grant No. ZR2023QC309), and the National Natural Science Foundation of China (Grant No. 32102236). We would like to thank Professor Miao Xuexia, Li Haichao and Shi Zhenying from the Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology Chinese Academy of Sciences for their invaluable assistance during the research.

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Abstract: Myeloblastosis (MYB) transcription factors, particularly those in the R2R3 MYB subclass, are pivotal in plant growth, development, and environmental stress responses. As one of the largest transcription factor families in plants, the MYB family significantly regulates plant secondary metabolism, including the biosynthetic pathways for phenylpropanoids, which are crucial for stress resistance. This review presents a comprehensive overview of MYB transcription factor classification and their regulatory mechanisms in plant metabolism and stress responses. We discuss the roles of MYB transcription factors in biotic stress resistance, such as defense against pathogens and pests, and in abiotic stress tolerance, including responses to drought and salinity. Special attention is given to the interactions of R2R3 MYB with other transcription factors and co-repressors, focusing on how these interactions in synergistic or antagonistic relationships with other proteins modulate various physiological processes. The multifunctional role of R2R3 MYBs in diverse stress responses positions them as promising targets for enhancing crop resilience through genetic breeding. Furthermore, this review underscores the potential applications of MYB transcription factors in developing stress-resistant crops and highlights new insights into their utility in plant resistance breeding programs.

Key words: rice, R2R3 MYB, biotic stress, abiotic stress, plant resistance breeding